The reference site for Medroxyprogesterone

Medroxyprogesterone (INN, BAN), also known as 17α-hydroxy-6α-methylprogesterone, and abbreviated as MP, is a steroidal progestin drug which was never marketed for use in humans.

WHAT IS MEDROXYPROGESTERONE?

Medroxyprogesterone is in a class of medications called progestins. It works by stopping the growth of the lining of the uterus and by causing the uterus to produce certain hormones.

Medroxyprogesterone is used to treat abnormal menstruation (periods) or irregular vaginal bleeding. It can also be used to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause.

This medicine is also used to prevent overgrowth of the lining of the uterus (womb) and may decrease the risk of cancer of the uterus in patients who are taking estrogen.

 

 

Brand Name(s): Amen, Curretab, Depo-Provera,Cycrin, Provera
CAS nº: 71-58-9
(me drox’ ee proe jes’ te rone)

 

Product Info

The sections below will provide you with more specific information and guidelines related to medroxyprogesterone and its correct use. Please read them carefully.

FDA Information

Medroxyprogesterone was originally approved by the US Food and Drug Administration in 1959.

In March 2005, the FDA approved a new treatment option for managing endometriosis pain, depo-subQ provera 104® (medroxyprogesterone acetate injectable suspension), manufactured by Pfizer Inc. This is the first approval of a drug to treat pain associated with the gynecological condition, which affects about 10% of women of reproductive age.

Why is this medication prescribed?

Medroxyprogesterone is in a class of medications called progestins. It works by stopping the growth of the lining of the uterus and by causing the uterus to produce certain hormones.

Medroxyprogesterone is used to treat abnormal menstruation (periods) or irregular vaginal bleeding. It can also be used to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause.

This medicine is also used to prevent overgrowth of the lining of the uterus (womb) and may decrease the risk of cancer of the uterus in patients who are taking estrogen.

Other uses for this medicine

Medroxyprogesterone may also be used in the treatment of inoperable, recurrent, and metastatic endometrial or renal carcinoma, as well as for the management of pain associated with endometriosis.

Dosage and using this medicine

Use medroxyprogesterone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse or doctor to explain them to you.

Medroxyprogesterone is usually injected by a healthcare provider. If you are injecting medroxyprogesterone at home, your doctor, nurse, or healthcare provider will give you detailed instructions on administration of the medication.

When used as birth control, the initial injection will be given during the first 5 days of a normal menstrual period, within the first 5 days after giving birth if not breast-feeding, or at the sixth week after giving birth if exclusively breast-feeding.

When used as birth control, medroxyprogesterone should be injected once every 3 months (13 weeks). It is important that each injection be given at exactly a 3 month interval to ensure continued contraceptive protection.

If medroxyprogesterone is being used in the treatment of cancer or for other purposes not described here, your doctor or healthcare provider will give you additional information regarding use and storage of the medication.

What special precautions should I follow?

BEFORE TAKING MEDROXYPROGESTERONE:

Tell your doctor if you have any of the following: high blood pressure, angina, or heart disease; had a stroke; a history of unusual bleeding or blood-clotting; liver disease; kidney disease; a personal or family history of breast cancer, uterine, or another hormone-related cancer; undiagnosed, abnormal vaginal bleeding; a history of intracranial hypertension (increased blood pressure in the head); problems with the eyes; osteoporosis; depression; migraines; diabetes; asthma; seizures or epilepsy. You may not be able to use medroxyprogesterone or you may require special monitoring during treatment if you have any of the conditions listed above.

Women who use medroxyprogesterone may lose significant bone mineral density. Bone loss is greater the longer the drug is used and may not be completely reversible. It is unknown if the use of medroxyprogesterone in adolescents or young adults will reduce bone mass and increase the risk for osteoporotic fracture in later life. Women should only use medroxyprogesterone as a long-term birth control method (longer than two years) if other birth control methods are inadequate.

If you are switching from the pill, patch or ring form of contraception to an injectable form of medroxyprogesterone contraception, the first injection should be administered within 7 days after taking the last active pill or removing the patch or ring. Similarly, contraceptive coverage can be maintained when switching from one form of injectable medroxyprogesterone to another if the next injection is given within your current scheduled dosing period. Talk to your doctor if you have any questions regarding your contraceptive coverage when switching products.

Medroxyprogesterone is in the FDA pregnancy category X. This means that medroxyprogesterone is known to cause birth defects in an unborn baby. Hormonal changes during pregnancy can have serious negative effects on a developing baby. Notify your doctor immediately if you think you might be pregnant.

Additionally, this drug passes into breast milk but does not appear to affect a nursing baby. Talk to your doctor before using medroxyprogesterone if you are breast-feeding a baby.

Avoid smoking cigarettes during treatment with medroxyprogesterone. Smoking may increase the risk of developing a heart attack, stroke, or blood clot.

Medroxyprogesterone contraceptive does not offer protection from sexually transmitted diseases including HIV and AIDS. Using a condom is the only way to obtain protection from these diseases.

What should I do if I forget a dose?

If a dose of medroxyprogesterone contraceptive is missed or delayed past the 3 month interval, another form of birth control should be used to ensure contraceptive protection. Contact your healthcare provider if a dose is missed or delayed.

On the other hand, contact your doctor if a dose of medroxyprogesterone is missed when being used in the treatment of cancer.

What side effects can this medication cause?

Possible side effects from medroxyprogesterone include:

skin reactions
hives
acne
hair growth
hair loss

Tell your doctor if any of these symptoms are severe or do not go away:

irregular, increased, or decreased menstrual bleeding
no menstrual bleeding at all
pain, swelling, or bruising at the injection site
headache or dizziness
nervousness
nausea
breast tenderness
changes in weight or appetite
oily skin or acne
changes in hair growth

If you experience any of the following symptoms, call your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
a blood clot in the lung (shortness of breath, pain in the chest, or coughing up blood)
a blood clot in an arm or leg (pain, redness, swelling, or numbness of an arm or leg)
severe headache or vomiting, dizziness or fainting, problems with eyesight or speech
weakness, or numbness in an arm or leg (indicating a possible stroke)
high blood pressure (severe headache, flushing, blurred vision)
liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue)
unusually heavy menstrual bleeding
persistent pain, puss, or bleeding at the injection site

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed and if necessary talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

nausea
menstrual irregularities
vaginal bleeding
vomiting

Product Images

PICTURES OF MEDROXYPROGESTERONE PILLS

Below you will find images and specific information on the principal types of medroxyprogesterone that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

 

Name: MEDROXYPROGESTERONE
Strength(s): 2.5 MG
Imprint: 555 872
Manufacturer: BARR LABS.

Name: MEDROXYPROGESTERONE
Strength(s): 2.5 MG
Imprint: G 3740
Manufacturer: GREENSTONE LTD.

Name: PROVERA®
Strength(s): 2.5 MG
Imprint: PROVERA 2.5
Manufacturer: PHARMACIA/UPJHN

Name: MEDROXYPROGESTERONE
Strength(s): 5 MG
Imprint: 555 873
Manufacturer: BARR LABS.

Name: MEDROXYPROGESTERONE
Strength(s): 5 MG
Imprint: G 3741
Manufacturer: GREENSTONE LTD.

Name: PROVERA®
Strength(s): 5 MG
Imprint: PROVERA 5
Manufacturer: PHARMACIA/UPJHN

Name: PROVERA®
Strength(s): 10 MG
Imprint: PROVERA 10
Manufacturer: PHARMACIA/UPJHN

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